Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies

Attempts at eradicating metastatic cancers with targeted therapies are limited by the emergence of resistant subclones bearing heterogeneous (epi)genetic changes. We used colorectal cancer (CRC) to test the hypothesis that interfering with an ancestral oncogenic event shared by all the malignant cel...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Russo, Mariangela, Lamba, Simona, Lorenzato, Annalisa, Sogari, Alberto, Corti, Giorgio, Rospo, Giuseppe, Mussolin, Benedetta, Montone, Monica, Lazzari, Luca, Arena, Sabrina, Oddo, Daniele, Linnebacher, Michael, Sartore-Bianchi, Andrea, Pietrantonio, Filippo, Siena, Salvatore, Di Nicolantonio, Federica, Bardelli, Alberto
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5997733/
https://ncbi.nlm.nih.gov/pubmed/29895949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04506-z
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