RAF Suppression Synergizes with MEK Inhibition in KRAS Mutant Cancer Cells

KRAS is the most frequently mutated oncogene in human cancer, yet no therapies are available to treat KRAS mutant cancers. We used two independent reverse genetic approaches to identify components of the RAS-signaling pathways required for growth of KRAS mutant tumors. Small interfering RNA (siRNA)...

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Bibliografiset tiedot
Päätekijät: Simona Lamba, Mariangela Russo, Chong Sun, Luca Lazzari, Carlotta Cancelliere, Wipawadee Grernrum, Cor Lieftink, Rene Bernards, Federica Di Nicolantonio, Alberto Bardelli
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Elsevier 2014-09-01
Sarja:Cell Reports
Linkit:http://www.sciencedirect.com/science/article/pii/S2211124714006172
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