A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers

BACKGROUND: Mutations in KRAS are frequent in human cancer, yet effective targeted therapeutics for these cancers are still lacking. Attempts to drug the MEK kinases downstream of KRAS have had limited success in clinical trials. Understanding the specific genomic vulnerabilities of KRAS-driven canc...

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Detalhes bibliográficos
Publicado no:Genome Med
Main Authors: Šuštić, Tonći, van Wageningen, Sake, Bosdriesz, Evert, Reid, Robert J. D., Dittmar, John, Lieftink, Cor, Beijersbergen, Roderick L., Wessels, Lodewyk F. A., Rothstein, Rodney, Bernards, René
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6258447/
https://ncbi.nlm.nih.gov/pubmed/30482246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-018-0600-z
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