MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models

Activation of the mitogen-activated protein kinase (MAPK) pathway is frequent in cancer. Drug development efforts have been focused on kinases in this pathway, most notably on RAF and MEK. We show here that MEK inhibition activates JNK-JUN signaling through suppression of DUSP4, leading to activatio...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Xue, Zheng, Vis, Daniel J., Bruna, Alejandra, Sustic, Tonci, van Wageningen, Sake, Batra, Ankita Sati, Rueda, Oscar M., Bosdriesz, Evert, Caldas, Carlos, Wessels, Lodewyk F. A., Bernards, René
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028652/
https://ncbi.nlm.nih.gov/pubmed/29795445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-018-0044-4
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