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RAF/MEK dependence of KRAS mutant pancreatic ductal adenocarcinomas

Studies employing genetically engineered mouse models indicate that RAF activation is sufficient to induce pancreas intraepithelial neoplasms (PanINs) suggesting that MEK inhibitor-based combination approaches may have clinical utility in patients with pancreatic ductal adenocarcinomas.

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Bibliographic Details
Published in:Cancer Discov
Main Authors: Hanrahan, Aphrothiti J., Solit, David B.
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5031078/
https://ncbi.nlm.nih.gov/pubmed/22886659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0308
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