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RAF/MEK dependence of KRAS mutant pancreatic ductal adenocarcinomas
Studies employing genetically engineered mouse models indicate that RAF activation is sufficient to induce pancreas intraepithelial neoplasms (PanINs) suggesting that MEK inhibitor-based combination approaches may have clinical utility in patients with pancreatic ductal adenocarcinomas.
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| Publicado en: | Cancer Discov |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5031078/ https://ncbi.nlm.nih.gov/pubmed/22886659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0308 |
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