Downstream of Mutant KRAS, the Transcription Regulator YAP Is Essential for Neoplastic Progression to Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor survival rates and frequently carries oncogenic KRAS mutation. However, KRAS has thus far not been a viable therapeutic target. We found that the abundance of YAP mRNA, which encodes Yes-associated protein (YAP), a protein reg...

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Detalhes bibliográficos
Main Authors: Zhang, Weiying, Nandakumar, Nivedita, Shi, Yuhao, Manzano, Mark, Smith, Alias, Graham, Garrett, Gupta, Swati, Vietsch, Eveline E., Laughlin, Sean Z., Wadhwa, Mandheer, Chetram, Mahandranauth, Joshi, Mrinmayi, Wang, Fen, Kallakury, Bhaskar, Toretsky, Jeffrey, Wellstein, Anton, Yi, Chunling
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175524/
https://ncbi.nlm.nih.gov/pubmed/24803537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005049
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