Downstream of Mutant KRAS, the Transcription Regulator YAP Is Essential for Neoplastic Progression to Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor survival rates and frequently carries oncogenic KRAS mutation. However, KRAS has thus far not been a viable therapeutic target. We found that the abundance of YAP mRNA, which encodes Yes-associated protein (YAP), a protein reg...

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Päätekijät: Zhang, Weiying, Nandakumar, Nivedita, Shi, Yuhao, Manzano, Mark, Smith, Alias, Graham, Garrett, Gupta, Swati, Vietsch, Eveline E., Laughlin, Sean Z., Wadhwa, Mandheer, Chetram, Mahandranauth, Joshi, Mrinmayi, Wang, Fen, Kallakury, Bhaskar, Toretsky, Jeffrey, Wellstein, Anton, Yi, Chunling
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175524/
https://ncbi.nlm.nih.gov/pubmed/24803537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005049
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