The cholesterol biosynthesis enzyme oxidosqualene cyclase is a new target to impair tumour angiogenesis and metastasis dissemination

Aberrant cholesterol homeostasis and biosynthesis has been observed in different tumour types. This paper investigates the role of the post-squalenic enzyme of cholesterol biosynthesis, oxidosqualene cyclase (OSC), in regulating tumour angiogenesis and metastasis dissemination in mouse models of can...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Maione, Federica, Oliaro-Bosso, Simonetta, Meda, Claudia, Di Nicolantonio, Federica, Bussolino, Federico, Balliano, Gianni, Viola, Franca, Giraudo, Enrico
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4357009/
https://ncbi.nlm.nih.gov/pubmed/25761781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09054
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