Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models

Tumor growth and progression rely upon angiogenesis, which is regulated by pro- and antiangiogenic factors, including members of the semaphorin family. By analyzing 3 different mouse models of multistep carcinogenesis, we show here that during angiogenesis, semaphorin 3A (Sema3A) is expressed in ECs...

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Bibliografiske detaljer
Main Authors: Maione, Federica, Molla, Fabiola, Meda, Claudia, Latini, Roberto, Zentilin, Lorena, Giacca, Mauro, Seano, Giorgio, Serini, Guido, Bussolino, Federico, Giraudo, Enrico
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769187/
https://ncbi.nlm.nih.gov/pubmed/19809158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36308
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