Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models

Tumor growth and progression rely upon angiogenesis, which is regulated by pro- and antiangiogenic factors, including members of the semaphorin family. By analyzing 3 different mouse models of multistep carcinogenesis, we show here that during angiogenesis, semaphorin 3A (Sema3A) is expressed in ECs...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Maione, Federica, Molla, Fabiola, Meda, Claudia, Latini, Roberto, Zentilin, Lorena, Giacca, Mauro, Seano, Giorgio, Serini, Guido, Bussolino, Federico, Giraudo, Enrico
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2009
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769187/
https://ncbi.nlm.nih.gov/pubmed/19809158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36308
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