Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human colorectal cancer models

BACKGROUND: Targeting the epidermal growth factor receptor (EGFR) either alone or in combination with chemotherapy is an effective treatment for patients with RAS wild-type metastatic colorectal cancer (mCRC). However, only a small percentage of mCRC patients receive clinical benefits from anti-EGFR...

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Publicat a:J Exp Clin Cancer Res
Autors principals: Belli, Valentina, Matrone, Nunzia, Napolitano, Stefania, Migliardi, Giorgia, Cottino, Francesca, Bertotti, Andrea, Trusolino, Livio, Martinelli, Erika, Morgillo, Floriana, Ciardiello, Davide, De Falco, Vincenzo, Giunta, Emilio Francesco, Bracale, Umberto, Ciardiello, Fortunato, Troiani, Teresa
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6549349/
https://ncbi.nlm.nih.gov/pubmed/31164152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1230-z
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