Antitumor efficacy of triple monoclonal antibody inhibition of epidermal growth factor receptor (EGFR) with MM151 in EGFR-dependent and in cetuximab-resistant human colorectal cancer cells

PURPOSE: We investigated the effect of triple monoclonal antibody inhibition of EGFR to overcome acquired resistance to first generation of anti-EGFR inhibitors. EXPERIMENTAL DESIGN: MM151 is a mixture of three different monoclonal IgG1 antibodies directed toward three different, non-overlapping, ep...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Napolitano, Stefania, Martini, Giulia, Martinelli, Erika, Della Corte, Carminia Maria, Morgillo, Floriana, Belli, Valentina, Cardone, Claudia, Matrone, Nunzia, Ciardiello, Fortunato, Troiani, Teresa
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669927/
https://ncbi.nlm.nih.gov/pubmed/29137301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19797
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