Receptor tyrosine kinase-dependent PI3K activation is an escape mechanism to vertical suppression of the EGFR/RAS/MAPK pathway in KRAS-mutated human colorectal cancer cell lines

BACKGROUND: Previous studies showed that the combination of an anti-Epidermal growth factor (EGFR) and a MEK-inhibitor is able to prevent the onset of resistance to anti-EGFR monoclonal antibodies in KRAS-wild type colorectal cancer (CRC), while the same combination reverts anti-EGFR primary resista...

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Vydáno v:J Exp Clin Cancer Res
Hlavní autoři: Vitiello, Pietro Paolo, Cardone, Claudia, Martini, Giulia, Ciardiello, Davide, Belli, Valentina, Matrone, Nunzia, Barra, Giusi, Napolitano, Stefania, Della Corte, Carmina, Turano, Mimmo, Furia, Maria, Troiani, Teresa, Morgillo, Floriana, De Vita, Ferdinando, Ciardiello, Fortunato, Martinelli, Erika
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6350302/
https://ncbi.nlm.nih.gov/pubmed/30691487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1035-0
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