HER2 activating mutations are targets for colorectal cancer treatment

The Cancer Genome Atlas project identified HER2 somatic mutations and gene amplification in 7% of colorectal cancer patients. Introduction of the HER2 mutations, S310F, L755S, V777L, V842I, and L866M, into colon epithelial cells increased signaling pathways and anchorage-independent cell growth, ind...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancer Discov
Egile Nagusiak: Kavuri, Shyam M., Jain, Naveen, Galimi, Francesco, Cottino, Francesca, Leto, Simonetta M., Migliardi, Giorgia, Searleman, Adam C., Shen, Wei, Monsey, John, Trusolino, Livio, Jacobs, Samuel A., Bertotti, Andrea, Bose, Ron
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527087/
https://ncbi.nlm.nih.gov/pubmed/26243863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-1211
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