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Her4 and Her2/neu Tyrosine Kinase Domains Dimerize and Activate in a Reconstituted in Vitro System

Her4 (ErbB-4) and Her2/neu (ErbB-2) are receptor-tyrosine kinases belonging to the epidermal growth factor receptor (EGFR) family. Crystal structures of EGFR and Her4 kinase domains demonstrate kinase dimerization and activation through an allosteric mechanism. The kinase domains form an asymmetric...

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Detalhes bibliográficos
Main Authors: Monsey, John, Shen, Wei, Schlesinger, Paul, Bose, Ron
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844153/
https://ncbi.nlm.nih.gov/pubmed/20022944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.096032
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