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Carboxyl Group Footprinting Mass Spectrometry and Molecular Dynamics Identify Key Interactions in the HER2-HER3 Receptor Tyrosine Kinase Interface

The HER2 receptor tyrosine kinase is a driver oncogene in many human cancers, including breast and gastric cancer. Under physiologic levels of expression, HER2 heterodimerizes with other members of the EGF receptor/HER/ErbB family, and the HER2-HER3 dimer forms one of the most potent oncogenic recep...

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Hlavní autoři: Collier, Timothy S., Diraviyam, Karthikeyan, Monsey, John, Shen, Wei, Sept, David, Bose, Ron
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757188/
https://ncbi.nlm.nih.gov/pubmed/23843458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.474882
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