Carboxyl-Group Footprinting Maps the Dimerization Interface and Phosphorylation-induced Conformational Changes of a Membrane-associated Tyrosine Kinase

Her4 is a transmembrane receptor tyrosine kinase belonging to the ErbB-EGFR family. It plays a vital role in the cardiovascular and nervous systems, and mutations in Her4 have been found in melanoma and lung cancer. The kinase domain of Her4 forms a dimer complex, called the asymmetric dimer, which...

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Bibliografiske detaljer
Main Authors: Zhang, Hao, Shen, Wei, Rempel, Don, Monsey, John, Vidavsky, Ilan, Gross, Michael L., Bose, Ron
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2011
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3108836/
https://ncbi.nlm.nih.gov/pubmed/21422241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M110.005678
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