Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

The development of noninvasive methods to detect and monitor tumors continues to be a major challenge in oncology. We used digital polymerase chain reaction–based technologies to evaluate the ability of circulating tumor DNA (ctDNA) to detect tumors in 640 patients with various cancer types. We foun...

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Detalhes bibliográficos
Main Authors: Bettegowda, Chetan, Sausen, Mark, Leary, Rebecca J., Kinde, Isaac, Wang, Yuxuan, Agrawal, Nishant, Bartlett, Bjarne R., Wang, Hao, Luber, Brandon, Alani, Rhoda M., Antonarakis, Emmanuel S., Azad, Nilofer S., Bardelli, Alberto, Brem, Henry, Cameron, John L., Lee, Clarence C., Fecher, Leslie A., Gallia, Gary L., Gibbs, Peter, Le, Dung, Giuntoli, Robert L., Goggins, Michael, Hogarty, Michael D., Holdhoff, Matthias, Hong, Seung-Mo, Jiao, Yuchen, Juhl, Hartmut H., Kim, Jenny J., Siravegna, Giulia, Laheru, Daniel A., Lauricella, Calogero, Lim, Michael, Lipson, Evan J., Marie, Suely Kazue Nagahashi, Netto, George J., Oliner, Kelly S., Olivi, Alessandro, Olsson, Louise, Riggins, Gregory J., Sartore-Bianchi, Andrea, Schmidt, Kerstin, Shih, le-Ming, Oba-Shinjo, Sueli Mieko, Siena, Salvatore, Theodorescu, Dan, Tie, Jeanne, Harkins, Timothy T., Veronese, Silvio, Wang, Tian-Li, Weingart, Jon D., Wolfgang, Christopher L., Wood, Laura D., Xing, Dongmei, Hruban, Ralph H., Wu, Jian, Allen, Peter J., Schmidt, C. Max, Choti, Michael A., Velculescu, Victor E., Kinzler, Kenneth W., Vogelstein, Bert, Papadopoulos, Nickolas, Diaz, Luis A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017867/
https://ncbi.nlm.nih.gov/pubmed/24553385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3007094
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