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Intratumoral concentrations of imatinib after oral administration in patients with glioblastoma multiforme
BACKGROUND: Imatinib, an orally administered tyrosine kinase inhibitor of PDGF receptor, c-abl and c-kit, is currently in clinical trials to assess its efficacy in malignant gliomas. Although imatinib does not readily penetrate an intact blood-brain barrier (BBB), the extent to which it distributes...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3927643/ https://ncbi.nlm.nih.gov/pubmed/19768386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-009-0008-0 |
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