Novel CAD-ALK gene rearrangement is drugable by entrectinib in colorectal cancer

BACKGROUND: Activated anaplastic lymphoma kinase (ALK) gene fusions are recurrent events in a small fraction of colorectal cancers (CRCs), although these events have not yet been exploited as in other malignancies. METHODS: We detected ALK protein expression by immunohistochemistry and gene rearrang...

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Vydáno v:Br J Cancer
Hlavní autoři: Amatu, Alessio, Somaschini, Alessio, Cerea, Giulio, Bosotti, Roberta, Valtorta, Emanuele, Buonandi, Pasquale, Marrapese, Giovanna, Veronese, Silvio, Luo, David, Hornby, Zachary, Multani, Pratik, Murphy, Danielle, Shoemaker, Robert, Lauricella, Calogero, Giannetta, Laura, Maiolani, Martina, Vanzulli, Angelo, Ardini, Elena, Galvani, Arturo, Isacchi, Antonella, Sartore-Bianchi, Andrea, Siena, Salvatore
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
Témata:
Short Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701996/
https://ncbi.nlm.nih.gov/pubmed/26633560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.401
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