Bypass Mechanisms of Resistance to Receptor Tyrosine Kinase Inhibition in Lung Cancer

Por Niederst, Matthew J., Engelman, Jeffrey A.
Publicado em 2013

EMT Twists the road to PI3Kinase

Por Niederst, Matthew J., Benes, Cyril H.
Publicado em 2014

Suppression of Survival Signalling Pathways by the Phosphatase PHLPP

Por O'Neill, Audrey K., Niederst, Matthew J., Newton, Alexandra C.
Publicado em 2012

Transformation from non-small-cell lung cancer to small-cell lung cancer: molecular drivers and cells of origin

Por Oser, Matthew G, Niederst, Matthew J, Sequist, Lecia V, Engelman, Jeffrey A
Publicado no Lancet Oncol (2015)

The allelic context of the C797S mutation acquired upon treatment with third generation EGFR inhibitors impacts sensitivity to subsequent treatment strategies

Por Niederst, Matthew J., Hu, Haichuan, Mulvey, Hillary E., Lockerman, Elizabeth L., Garcia, Angel R., Piotrowska, Zofia, Sequist, Lecia V., Engelman, Jeffrey A.
Publicado no Clin Cancer Res (2015)

Heterogeneity Underlies the Emergence of EGFR T790 Wild-Type Clones Following Treatment of T790M-Positive Cancers with a Third Generation EGFR Inhibitor

Por Piotrowska, Zofia, Niederst, Matthew J., Karlovich, Chris A., Wakelee, Heather A., Neal, Joel W., Mino-Kenudson, Mari, Fulton, Linnea, Hata, Aaron N., Lockerman, Elizabeth L., Kalsy, Anuj, Digumarthy, Subba, Muzikansky, Alona, Raponi, Mitch, Garcia, Angel R., Mulvey, Hillary E., Parks, Melissa K., DiCecca, Richard H., Dias-Santagata, Dora, Iafrate, A. John, Shaw, Alice T., Allen, Andrew R., Engelman, Jeffrey A., Sequist, Lecia V.
Publicado no Cancer Discov (2015)

KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer

Por Krall, Elsa B, Wang, Belinda, Munoz, Diana M, Ilic, Nina, Raghavan, Srivatsan, Niederst, Matthew J, Yu, Kristine, Ruddy, David A, Aguirre, Andrew J, Kim, Jong Wook, Redig, Amanda J, Gainor, Justin F, Williams, Juliet A, Asara, John M, Doench, John G, Janne, Pasi A, Shaw, Alice T, McDonald III, Robert E, Engelman, Jeffrey A, Stegmeier, Frank, Schlabach, Michael R, Hahn, William C
Publicado no eLife (2017)

Patient-derived Models of Acquired Resistance Can Identify Effective Drug Combinations for Cancer

Por Crystal, Adam S., Shaw, Alice T., Sequist, Lecia V., Friboulet, Luc, Niederst, Matthew J., Lockerman, Elizabeth L., Frias, Rosa L., Gainor, Justin F., Amzallag, Arnaud, Greninger, Patricia, Lee, Dana, Kalsy, Anuj, Gomez-Caraballo, Maria, Elamine, Leila, Howe, Emily, Hur, Wooyoung, Lifshits, Eugene, Robinson, Hayley E., Katayama, Ryohei, Faber, Anthony C., Awad, Mark M., Ramaswamy, Sridhar, Mino-Kenudson, Mari, Iafrate, A. John, Benes, Cyril H., Engelman, Jeffrey A.
Publicado no Science (2014)

RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer

Por Niederst, Matthew J., Sequist, Lecia V., Poirier, John T., Mermel, Craig H., Lockerman, Elizabeth L., Garcia, Angel R., Katayama, Ryohei, Costa, Carlotta, Ross, Kenneth N., Moran, Teresa, Howe, Emily, Fulton, Linnea E., Mulvey, Hillary E., Bernardo, Lindsay A., Mohamoud, Farhiya, Miyoshi, Norikatsu, VanderLaan, Paul A., Costa, Daniel B., Jänne, Pasi A., Borger, Darrell R., Ramaswamy, Sridhar, Shioda, Toshi, Iafrate, Anthony J., Getz, Gad, Rudin, Charles M., Mino-Kenudson, Mari, Engelman, Jeffrey A.
Publicado no Nat Commun (2015)

Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition

Por Hata, Aaron N, Niederst, Matthew J, Archibald, Hannah L, Gomez-Caraballo, Maria, Siddiqui, Faria M, Mulvey, Hillary E, Maruvka, Yosef E, Ji, Fei, Bhang, Hyo-eun C, Radhakrishna, Viveksagar Krishnamurthy, Siravegna, Giulia, Hu, Haichuan, Raoof, Sana, Lockerman, Elizabeth, Kalsy, Anuj, Lee, Dana, Keating, Celina L, Ruddy, David A, Damon, Leah J, Crystal, Adam S, Costa, Carlotta, Piotrowska, Zofia, Bardelli, Alberto, Iafrate, Anthony J, Sadreyev, Ruslan I, Stegmeier, Frank, Getz, Gad, Sequist, Lecia V, Faber, Anthony C, Engelman, Jeffrey A
Publicado no Nat Med (2016)