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Bypass Mechanisms of Resistance to Receptor Tyrosine Kinase Inhibition in Lung Cancer

Receptor tyrosine kinases (RTKs) are activated by somatic genetic alterations in a subset of cancers, and such cancers are often sensitive to specific inhibitors of the activated kinase. Two well-established examples of this paradigm include lung cancers with either EGFR mutations or ALK translocati...

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Detalhes bibliográficos
Main Authors: Niederst, Matthew J., Engelman, Jeffrey A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876281/
https://ncbi.nlm.nih.gov/pubmed/24065147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2004652
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