Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue

BACKGROUND: Topoisomerase II poisons are in clinical use as anti-cancer therapy for decades and work by stabilizing the enzyme-induced DNA breaks. In contrast, catalytic inhibitors block the enzyme before DNA scission. Although several catalytic inhibitors of topoisomerase II have been described, pr...

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מידע ביבליוגרפי
Main Authors: Chène, Patrick, Rudloff, Joëlle, Schoepfer, Joseph, Furet, Pascal, Meier, Peter, Qian, Zhiyan, Schlaeppi, Jean-Marc, Schmitz, Rita, Radimerski, Thomas
פורמט: Artigo
שפה:Inglês
יצא לאור: BioMed Central 2009
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628638/
https://ncbi.nlm.nih.gov/pubmed/19128485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6769-9-1
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