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Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue
BACKGROUND: Topoisomerase II poisons are in clinical use as anti-cancer therapy for decades and work by stabilizing the enzyme-induced DNA breaks. In contrast, catalytic inhibitors block the enzyme before DNA scission. Although several catalytic inhibitors of topoisomerase II have been described, pr...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2628638/ https://ncbi.nlm.nih.gov/pubmed/19128485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6769-9-1 |
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