Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling

Por Radimerski, Thomas, Montagne, Jacques, Hemmings-Mieszczak, Maja, Thomas, George
Publicado em 2002

Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin

Por Oldham, Sean, Montagne, Jacques, Radimerski, Thomas, Thomas, George, Hafen, Ernst
Publicado em 2000

Bim and Mcl-1 exert key roles in regulating JAK2(V617F )cell survival

Por Rubert, Joëlle, Qian, Zhiyan, Andraos, Rita, Guthy, Daniel A, Radimerski, Thomas
Publicado em 2011

The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling

Por Jünger, Martin A, Rintelen, Felix, Stocker, Hugo, Wasserman, Jonathan D, Végh, Mátyás, Radimerski, Thomas, Greenberg, Michael E, Hafen, Ernst
Publicado em 2003

Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue

Por Chène, Patrick, Rudloff, Joëlle, Schoepfer, Joseph, Furet, Pascal, Meier, Peter, Qian, Zhiyan, Schlaeppi, Jean-Marc, Schmitz, Rita, Radimerski, Thomas
Publicado em 2009

HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia

Por Akahane, Koshi, Sanda, Takaomi, Mansour, Marc R., Radimerski, Thomas, DeAngelo, Daniel J., Weinstock, David M., Look, A. Thomas
Publicado no Leukemia (2015)

NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models

Por Jensen, Michael Rugaard, Schoepfer, Joseph, Radimerski, Thomas, Massey, Andrew, Guy, Chantale T, Brueggen, Josef, Quadt, Cornelia, Buckler, Alan, Cozens, Robert, Drysdale, Martin J, Garcia-Echeverria, Carlos, Chène, Patrick
Publicado em 2008

The Nuclear Receptor DHR3 Modulates dS6 Kinase–Dependent Growth in Drosophila

Por Montagne, Jacques, Lecerf, Caroline, Parvy, Jean-Philippe, Bennion, Janis M., Radimerski, Thomas, Ruhf, Marie-Laure, Zilbermann, Frederic, Vouilloz, Nicole, Stocker, Hugo, Hafen, Ernst, Kozma, Sara C., Thomas, George
Publicado em 2010

JAK-STAT Pathway Activation in Malignant and Non-Malignant Cells Contributes to MPN Pathogenesis and Therapeutic Response

Por Kleppe, Maria, Kwak, Minsuk, Koppikar, Priya, Riester, Markus, Keller, Matthew, Bastian, Lennart, Hricik, Todd, Bhagwat, Neha, McKenney, Anna Sophia, Papalexi, Efthymia, Abdel-Wahab, Omar, Rampal, Raajit, Marubayashi, Sachie, Chen, Jonathan J., Romanet, Vincent, Fridman, Jordan S., Bromberg, Jacqueline, Teruya-Feldstein, Julie, Murakami, Masato, Radimerski, Thomas, Michor, Franziska, Fan, Rong, Levine, Ross L.
Publicado no Cancer Discov (2015)

Modulation of activation-loop phosphorylation by JAK inhibitors is binding mode dependent

Por Andraos, Rita, Qian, Zhiyan, Bonenfant, Débora, Rubert, Joëlle, Vangrevelinghe, Eric, Scheufler, Clemens, Marque, Fanny, Régnier, Catherine H., De Pover, Alain, Ryckelynck, Hugues, Bhagwat, Neha, Koppikar, Priya, Goel, Aviva, Wyder, Lorenza, Tavares, Gisele, Baffert, Fabienne, Pissot-Soldermann, Carole, Manley, Paul W., Gaul, Christoph, Voshol, Hans, Levine, Ross L., Sellers, William R., Hofmann, Francesco, Radimerski, Thomas
Publicado no Cancer Discov (2012)

Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition

Por Weigert, Oliver, Lane, Andrew A., Bird, Liat, Kopp, Nadja, Chapuy, Bjoern, van Bodegom, Diederik, Toms, Angela V., Marubayashi, Sachie, Christie, Amanda L., McKeown, Michael, Paranal, Ronald M., Bradner, James E., Yoda, Akinori, Gaul, Christoph, Vangrevelinghe, Eric, Romanet, Vincent, Murakami, Masato, Tiedt, Ralph, Ebel, Nicolas, Evrot, Emeline, De Pover, Alain, Régnier, Catherine H., Erdmann, Dirk, Hofmann, Francesco, Eck, Michael J., Sallan, Stephen E., Levine, Ross L., Kung, Andrew L., Baffert, Fabienne, Radimerski, Thomas, Weinstock, David M.
Publicado em 2012

CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms

Por Meyer, Sara C., Keller, Matthew D., Chiu, Sophia, Koppikar, Priya, Guryanova, Olga A., Rapaport, Franck, Xu, Ke, Manova, Katia, Pankov, Dmitry, O’Reilly, Richard J., Kleppe, Maria, McKenney, Anna Sophia, Shih, Alan H., Shank, Kaitlyn, Ahn, Jihae, Papalexi, Eftymia, Spitzer, Barbara, Socci, Nick, Viale, Agnes, Mandon, Emeline, Ebel, Nicolas, Andraos, Rita, Rubert, Joëlle, Dammassa, Ernesta, Romanet, Vincent, Dölemeyer, Arno, Zender, Michael, Heinlein, Melanie, Rampal, Rajit, Weinberg, Rona Singer, Hoffman, Ron, Sellers, William R., Hofmann, Francesco, Murakami, Masato, Baffert, Fabienne, Gaul, Christoph, Radimerski, Thomas, Levine, Ross L.
Publicado no Cancer Cell (2015)

Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia

Por Frismantas, Viktoras, Dobay, Maria Pamela, Rinaldi, Anna, Tchinda, Joelle, Dunn, Samuel H., Kunz, Joachim, Richter-Pechanska, Paulina, Marovca, Blerim, Pail, Orrin, Jenni, Silvia, Diaz-Flores, Ernesto, Chang, Bill H., Brown, Timothy J., Collins, Robert H., Uhrig, Sebastian, Balasubramanian, Gnana P., Bandapalli, Obul R., Higi, Salome, Eugster, Sabrina, Voegeli, Pamela, Delorenzi, Mauro, Cario, Gunnar, Loh, Mignon L., Schrappe, Martin, Stanulla, Martin, Kulozik, Andreas E., Muckenthaler, Martina U., Saha, Vaskar, Irving, Julie A., Meisel, Roland, Radimerski, Thomas, Von Stackelberg, Arend, Eckert, Cornelia, Tyner, Jeffrey W., Horvath, Peter, Bornhauser, Beat C., Bourquin, Jean-Pierre
Publicado no Blood (2017)

Activity of the type II JAK2 inhibitor CHZ868 in B-cell acute lymphoblastic leukemia

Por Wu, Shuo-Chieh, Li, Loretta S., Kopp, Nadja, Montero, Joan, Chapuy, Bjoern, Yoda, Akinori, Christie, Amanda L., Liu, Huiyun, Christodoulou, Alexandra, van Bodegom, Diederik, van der Zwet, Jordy, Layer, Jacob V., Tivey, Trevor, Lane, Andrew A., Ryan, Jeremy A., Ng, Samuel Y., DeAngelo, Daniel J., Stone, Richard M., Steensma, David, Wadleigh, Martha, Harris, Marian, Mandon, Emeline, Ebel, Nicolas, Andraos, Rita, Romanet, Vincent, Dölemeyer, Arno, Sterker, Dario, Zender, Michael, Rodig, Scott J., Murakami, Masato, Hofmann, Francesco, Kuo, Frank, Eck, Michael J., Silverman, Lewis B., Sallan, Stephen E., Letai, Anthony, Baffert, Fabienne, Vangrevelinghe, Eric, Radimerski, Thomas, Gaul, Christoph, Weinstock, David M.
Publicado no Cancer Cell (2015)