Apoptosis and cancer drug targeting

Por Sellers, William R., Fisher, David E.
Publicado em 1999

Oncogene addiction: pathways of therapeutic response, resistance, and road maps toward a cure

Por Pagliarini, Raymond, Shao, Wenlin, Sellers, William R
Publicado no EMBO Rep (2015)

Ribociclib (LEE011): mechanism of action and clinical impact of this selective cyclin-dependent kinase 4/6 inhibitor in various solid tumors

Por Tripathy, Debu, Bardia, Aditya, Sellers, William R.
Publicado no Clin Cancer Res (2017)

Big Data Approaches for Modeling Response and Resistance to Cancer Drugs

Por Jiang, Peng, Sellers, William R., Liu, X. Shirley
Publicado no Annu Rev Biomed Data Sci (2018)

Phosphorylation of the PTEN Tail Regulates Protein Stability and Function

Por Vazquez, Francisca, Ramaswamy, Shivapriya, Nakamura, Noriaki, Sellers, William R.
Publicado em 2000

Forkhead Transcription Factors Are Critical Effectors of Cell Death and Cell Cycle Arrest Downstream of PTEN

Por Nakamura, Noriaki, Ramaswamy, Shivapriya, Vazquez, Francisca, Signoretti, Sabina, Loda, Massimo, Sellers, William R.
Publicado em 2000

Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane

Por Vazquez, Francisca, Matsuoka, Satomi, Sellers, William R., Yanagida, Toshio, Ueda, Masahiro, Devreotes, Peter N.
Publicado em 2006

GEMINI: a variational Bayesian approach to identify genetic interactions from combinatorial CRISPR screens

Por Zamanighomi, Mahdi, Jain, Sidharth S., Ito, Takahiro, Pal, Debjani, Daley, Timothy P., Sellers, William R.
Publicado no Genome Biol (2019)

PTEN Nuclear Localization Is Regulated by Oxidative Stress and Mediates p53-Dependent Tumor Suppression

Por Chang, Chun-Ju, Mulholland, David J., Valamehr, Bahram, Mosessian, Sherly, Sellers, William R., Wu, Hong
Publicado em 2008

Regulation of G(1) progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

Por Ramaswamy, Shivapriya, Nakamura, Noriaki, Vazquez, Francisca, Batt, David B., Perera, Sauni, Roberts, Thomas M., Sellers, William R.
Publicado em 1999

Identification of prostate cancer modifier pathways using parental strain expression mapping

Por Xu, Qing, Majumder, Pradip K., Ross, Kenneth, Shim, Yeonju, Golub, Todd R., Loda, Massimo, Sellers, William R.
Publicado em 2007

SNP panel identification assay (SPIA): a genetic-based assay for the identification of cell lines

Por Demichelis, Francesca, Greulich, Heidi, Macoska, Jill A., Beroukhim, Rameen, Sellers, William R., Garraway, Levi, Rubin, Mark A.
Publicado em 2008

Major copy proportion analysis of tumor samples using SNP arrays

Por Li, Cheng, Beroukhim, Rameen, Weir, Barbara A, Winckler, Wendy, Garraway, Levi A, Sellers, William R, Meyerson, Matthew
Publicado em 2008

PIK3CA mutation uncouples tumor growth and Cyclin D1 regulation from MEK/ERK and mutant KRAS signaling

Por Halilovic, Ensar, She, Qing-Bai, Ye, Qing, Pagliarini, Raymond, Sellers, William R., Solit, David B., Rosen, Neal
Publicado em 2010

A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens

Por Hsieh, Andrew C., Bo, Ronghai, Manola, Judith, Vazquez, Francisca, Bare, Olivia, Khvorova, Anastasia, Scaringe, Stephen, Sellers, William R.
Publicado em 2004

Allele-Specific Amplification in Cancer Revealed by SNP Array Analysis

Por LaFramboise, Thomas, Weir, Barbara A, Zhao, Xiaojun, Beroukhim, Rameen, Li, Cheng, Harrington, David, Sellers, William R, Meyerson, Matthew
Publicado em 2005

p85 Associates with Unphosphorylated PTEN and the PTEN-Associated Complex

Por Rabinovsky, Rosalia, Pochanard, Panisa, McNear, Chontelle, Brachmann, Saskia M., Duke-Cohan, Jonathan S., Garraway, Levi A., Sellers, William R.
Publicado em 2009

Retinoblastoma Protein Contains a C-terminal Motif That Targets It for Phosphorylation by Cyclin-cdk Complexes

Por Adams, Peter D., Li, Xiaotong, Sellers, William R., Baker, Kayla B., Leng, Xiaohong, Harper, J. Wade, Taya, Yoichi, Kaelin, William G.
Publicado em 1999

Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth

Por Sellers, William R., Novitch, Bennett G., Miyake, Satoshi, Heith, Agnieszka, Otterson, Gregory A., Kaye, Frederic J., Lassar, Andrew B., Kaelin, William G.
Publicado em 1998

M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth

Por Cortés-Cros, Marta, Hemmerlin, Christelle, Ferretti, Stephane, Zhang, Juan, Gounarides, John S., Yin, Hong, Muller, Alban, Haberkorn, Anne, Chene, Patrick, Sellers, William R., Hofmann, Francesco
Publicado em 2013