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PTEN Nuclear Localization Is Regulated by Oxidative Stress and Mediates p53-Dependent Tumor Suppression

The tumor suppressor gene PTEN (phosphatase and tensin homologue deleted on chromosome 10) is frequently mutated or deleted in various human cancers. PTEN localizes predominantly to the cytoplasm and functions as a lipid phosphatase, thereby negatively regulating the phosphatidylinositol 3-kinase-AK...

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Bibliografiska uppgifter
Huvudupphovsmän: Chang, Chun-Ju, Mulholland, David J., Valamehr, Bahram, Mosessian, Sherly, Sellers, William R., Wu, Hong
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2008
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423144/
https://ncbi.nlm.nih.gov/pubmed/18332125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00310-08
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