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PTEN Nuclear Localization Is Regulated by Oxidative Stress and Mediates p53-Dependent Tumor Suppression

The tumor suppressor gene PTEN (phosphatase and tensin homologue deleted on chromosome 10) is frequently mutated or deleted in various human cancers. PTEN localizes predominantly to the cytoplasm and functions as a lipid phosphatase, thereby negatively regulating the phosphatidylinositol 3-kinase-AK...

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Autores principales: Chang, Chun-Ju, Mulholland, David J., Valamehr, Bahram, Mosessian, Sherly, Sellers, William R., Wu, Hong
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423144/
https://ncbi.nlm.nih.gov/pubmed/18332125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00310-08
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