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p85 Associates with Unphosphorylated PTEN and the PTEN-Associated Complex
The lipid phosphatase PTEN functions as a tumor suppressor by dephosphorylating the D3 position of phosphoinositide-3,4,5-trisphosphate, thereby negatively regulating the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway. In mammalian cells, PTEN exists either as a monomer or as a part of a >...
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| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2747981/ https://ncbi.nlm.nih.gov/pubmed/19635806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01649-08 |
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