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Insight into the PTEN – p85α interaction and lipid binding properties of the p85α BH domain

The phosphatidylinositol 3-kinase (PI3K) pathway plays a key role in regulating cell growth and cell survival and is frequently deregulated in cancer cells. p85α regulates the p110α lipid kinase, and also stabilizes and stimulates PTEN, the lipid phosphatase that downregulates this pathway. In this...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Marshall, Jeremy D.S., Mellor, Paul, Ruan, Xuan, Whitecross, Dielle E., Moore, Stanley A., Anderson, Deborah H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6319338/
https://ncbi.nlm.nih.gov/pubmed/30651929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26432
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