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Patient-derived mutations within the N-terminal domains of p85α impact PTEN or Rab5 binding and regulation
The p85α protein regulates flux through the PI3K/PTEN signaling pathway, and also controls receptor trafficking via regulation of Rab-family GTPases. In this report, we determined the impact of several cancer patient-derived p85α mutations located within the N-terminal domains of p85α previously sho...
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| Publicat a: | Sci Rep |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5940657/ https://ncbi.nlm.nih.gov/pubmed/29740032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25487-5 |
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