Patient-derived mutations within the N-terminal domains of p85α impact PTEN or Rab5 binding and regulation

The p85α protein regulates flux through the PI3K/PTEN signaling pathway, and also controls receptor trafficking via regulation of Rab-family GTPases. In this report, we determined the impact of several cancer patient-derived p85α mutations located within the N-terminal domains of p85α previously sho...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Mellor, Paul, Marshall, Jeremy D. S., Ruan, Xuan, Whitecross, Dielle E., Ross, Rebecca L., Knowles, Margaret A., Moore, Stanley A., Anderson, Deborah H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940657/
https://ncbi.nlm.nih.gov/pubmed/29740032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25487-5
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