Regulation of G(1) progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

PTEN/MMAC1 is a tumor suppressor gene located on chromosome 10q23. Inherited PTEN/MMAC1 mutations are associated with a cancer predisposition syndrome known as Cowden’s disease. Somatic mutation of PTEN has been found in a number of malignancies, including glioblastoma, melanoma, and carcinoma of th...

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Main Authors: Ramaswamy, Shivapriya, Nakamura, Noriaki, Vazquez, Francisca, Batt, David B., Perera, Sauni, Roberts, Thomas M., Sellers, William R.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1999
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC26745/
https://ncbi.nlm.nih.gov/pubmed/10051603
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