Regulation of G(1) progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

PTEN/MMAC1 is a tumor suppressor gene located on chromosome 10q23. Inherited PTEN/MMAC1 mutations are associated with a cancer predisposition syndrome known as Cowden’s disease. Somatic mutation of PTEN has been found in a number of malignancies, including glioblastoma, melanoma, and carcinoma of th...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Ramaswamy, Shivapriya, Nakamura, Noriaki, Vazquez, Francisca, Batt, David B., Perera, Sauni, Roberts, Thomas M., Sellers, William R.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1999
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26745/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10051603/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.5.2110
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