Oncogene addiction: pathways of therapeutic response, resistance, and road maps toward a cure

Por Pagliarini, Raymond, Shao, Wenlin, Sellers, William R
Publicado no EMBO Rep (2015)

Basement membrane remodeling is essential for Drosophila disc eversion and tumor invasion

Por Srivastava, Ajay, Pastor-Pareja, Jose Carlos, Igaki, Tatsushi, Pagliarini, Raymond, Xu, Tian
Publicado em 2007

PIK3CA mutation uncouples tumor growth and Cyclin D1 regulation from MEK/ERK and mutant KRAS signaling

Por Halilovic, Ensar, She, Qing-Bai, Ye, Qing, Pagliarini, Raymond, Sellers, William R., Solit, David B., Rosen, Neal
Publicado em 2010

A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53

Por Sur, Surojit, Pagliarini, Raymond, Bunz, Fred, Rago, Carlo, Diaz, Luis A., Kinzler, Kenneth W., Vogelstein, Bert, Papadopoulos, Nickolas
Publicado em 2009

Identification of Mixed Lineage Leukemia 1(MLL1) Protein as a Coactivator of Heat Shock Factor 1(HSF1) Protein in Response to Heat Shock Protein 90 (HSP90) Inhibition

Por Chen, Yaoyu, Chen, Jinyun, Yu, Jianjun, Yang, Guizhi, Temple, Emilia, Harbinski, Fred, Gao, Hui, Wilson, Christopher, Pagliarini, Raymond, Zhou, Wenlai
Publicado em 2014

Isocitrate Dehydrogenase (IDH) Mutations Promote a Reversible ZEB1/MicroRNA (miR)-200-dependent Epithelial-Mesenchymal Transition (EMT)

Por Grassian, Alexandra R., Lin, Fallon, Barrett, Rosemary, Liu, Yue, Jiang, Wei, Korpal, Manav, Astley, Holly, Gitterman, Daniel, Henley, Thomas, Howes, Rob, Levell, Julian, Korn, Joshua M., Pagliarini, Raymond
Publicado em 2012

Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth

Por Chen, Jinyun, Chung, Franklin, Yang, Guizhi, Pu, Minying, Gao, Hui, Jiang, Wei, Yin, Hong, Capka, Vladimir, Kasibhatla, Shailaja, Laffitte, Bryan, Jaeger, Savina, Pagliarini, Raymond, Chen, Yaoyu, Zhou, Wenlai
Publicado em 2013

A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein

Por Pop, Marius S, Stransky, Nicolas, Garvie, Colin W, Theurillat, Jean-Philippe, Lewis, Timothy A, Zhong, Cheng, Culyba, Elizabeth K, Lin, Fallon, Daniels, Douglas S, Pagliarini, Raymond, Ronco, Lucienne, Koehler, Angela N, Garraway, Levi A
Publicado em 2014

Targeting HSF1 sensitizes cancer cells to HSP90 inhibition

Por Chen, Yaoyu, Chen, Jinyun, Loo, Alice, Jaeger, Savina, Bagdasarian, Linda, Yu, Jianjun, Chung, Franklin, Korn, Joshua, Ruddy, David, Guo, Ribo, Mclaughlin, Margaret E., Feng, Fei, Zhu, Ping, Stegmeier, Frank, Pagliarini, Raymond, Porter, Dale, Zhou, Wenlai
Publicado em 2013

IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism

Por Grassian, Alexandra R., Parker, Seth J., Davidson, Shawn M., Divakarun, Ajit S., Green, Courtney R., Zhang, Xiamei, Slocum, Kelly L., Pu, Minying, Lin, Fallon, Vickers, Chad, Joud-Caldwell, Carol, Chung, Franklin, Yin, Hong, Handly, Erika D., Straub, Christopher, Growney, Joseph D., Vander Heiden, Matthew G., Murphy, Anne N., Pagliarini, Raymond, Metallo, Christian M.
Publicado no Cancer Res (2014)

ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor

Por Mounir, Zineb, Korn, Joshua M, Westerling, Thomas, Lin, Fallon, Kirby, Christina A, Schirle, Markus, McAllister, Gregg, Hoffman, Greg, Ramadan, Nadire, Hartung, Anke, Feng, Yan, Kipp, David Randal, Quinn, Christopher, Fodor, Michelle, Baird, Jason, Schoumacher, Marie, Meyer, Ronald, Deeds, James, Buchwalter, Gilles, Stams, Travis, Keen, Nicholas, Sellers, William R, Brown, Myles, Pagliarini, Raymond A
Publicado no eLife (2016)

Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1

Por Levell, Julian R., Caferro, Thomas, Chenail, Gregg, Dix, Ina, Dooley, Julia, Firestone, Brant, Fortin, Pascal D., Giraldes, John, Gould, Ty, Growney, Joseph D., Jones, Michael D., Kulathila, Raviraj, Lin, Fallon, Liu, Gang, Mueller, Arne, van der Plas, Simon, Slocum, Kelly, Smith, Troy, Terranova, Remi, Touré, B. Barry, Tyagi, Viraj, Wagner, Trixie, Xie, Xiaoling, Xu, Ming, Yang, Fan S., Zhou, Liping X., Pagliarini, Raymond, Cho, Young Shin
Publicado no ACS Med Chem Lett (2016)