Targeting HSF1 sensitizes cancer cells to HSP90 inhibition

The molecular chaperone heat shock protein 90 (HSP90) facilitates the appropriate folding of various oncogenic proteins and is necessary for the survival of some cancer cells. HSP90 is therefore an attractive drug target, but the efficacy of HSP90 inhibitor may be limited by HSP90 inhibition induced...

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Detalhes bibliográficos
Main Authors: Chen, Yaoyu, Chen, Jinyun, Loo, Alice, Jaeger, Savina, Bagdasarian, Linda, Yu, Jianjun, Chung, Franklin, Korn, Joshua, Ruddy, David, Guo, Ribo, Mclaughlin, Margaret E., Feng, Fei, Zhu, Ping, Stegmeier, Frank, Pagliarini, Raymond, Porter, Dale, Zhou, Wenlai
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757240/
https://ncbi.nlm.nih.gov/pubmed/23615731
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