Targeting HSF1 sensitizes cancer cells to HSP90 inhibition

The molecular chaperone heat shock protein 90 (HSP90) facilitates the appropriate folding of various oncogenic proteins and is necessary for the survival of some cancer cells. HSP90 is therefore an attractive drug target, but the efficacy of HSP90 inhibitor may be limited by HSP90 inhibition induced...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Chen, Yaoyu, Chen, Jinyun, Loo, Alice, Jaeger, Savina, Bagdasarian, Linda, Yu, Jianjun, Chung, Franklin, Korn, Joshua, Ruddy, David, Guo, Ribo, Mclaughlin, Margaret E., Feng, Fei, Zhu, Ping, Stegmeier, Frank, Pagliarini, Raymond, Porter, Dale, Zhou, Wenlai
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2013
Pynciau:
Research Papers
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757240/
https://ncbi.nlm.nih.gov/pubmed/23615731
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg