Identification of Mixed Lineage Leukemia 1(MLL1) Protein as a Coactivator of Heat Shock Factor 1(HSF1) Protein in Response to Heat Shock Protein 90 (HSP90) Inhibition

Heat shock protein 90 (HSP90) inhibition inhibits cancer cell proliferation through depleting client oncoproteins and shutting down multiple oncogenic pathways. Therefore, it is an attractive strategy for targeting human cancers. Several HSP90 inhibitors, including AUY922 and STA9090, show promising...

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Bibliografiske detaljer
Main Authors: Chen, Yaoyu, Chen, Jinyun, Yu, Jianjun, Yang, Guizhi, Temple, Emilia, Harbinski, Fred, Gao, Hui, Wilson, Christopher, Pagliarini, Raymond, Zhou, Wenlai
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081932/
https://ncbi.nlm.nih.gov/pubmed/24831003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.574053
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