Identification of Mixed Lineage Leukemia 1(MLL1) Protein as a Coactivator of Heat Shock Factor 1(HSF1) Protein in Response to Heat Shock Protein 90 (HSP90) Inhibition

Heat shock protein 90 (HSP90) inhibition inhibits cancer cell proliferation through depleting client oncoproteins and shutting down multiple oncogenic pathways. Therefore, it is an attractive strategy for targeting human cancers. Several HSP90 inhibitors, including AUY922 and STA9090, show promising...

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Detalhes bibliográficos
Main Authors: Chen, Yaoyu, Chen, Jinyun, Yu, Jianjun, Yang, Guizhi, Temple, Emilia, Harbinski, Fred, Gao, Hui, Wilson, Christopher, Pagliarini, Raymond, Zhou, Wenlai
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081932/
https://ncbi.nlm.nih.gov/pubmed/24831003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.574053
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