PTEN-deficient cancers depend on PIK3CB

по Wee, Susan, Wiederschain, Dmitri, Maira, Sauveur-Michel, Loo, Alice, Miller, Christine, deBeaumont, Rosalie, Stegmeier, Frank, Yao, Yung-Mae, Lengauer, Christoph
Опубликовано 2008

Patient-derived glioblastoma cultures as a tool for small-molecule drug discovery

по Ye, Ling F., Reznik, Eduard, Korn, Joshua M., Lin, Fallon, Yang, Guizhi, Malesky, Kimberly, Gao, Hui, Loo, Alice, Pagliarini, Raymond, Mikkelsen, Tom, Lo, Donald C., deCarvalho, Ana C., Stockwell, Brent R.
Опубликовано в: Oncotarget (2020)

Targeting HSF1 sensitizes cancer cells to HSP90 inhibition

по Chen, Yaoyu, Chen, Jinyun, Loo, Alice, Jaeger, Savina, Bagdasarian, Linda, Yu, Jianjun, Chung, Franklin, Korn, Joshua, Ruddy, David, Guo, Ribo, Mclaughlin, Margaret E., Feng, Fei, Zhu, Ping, Stegmeier, Frank, Pagliarini, Raymond, Porter, Dale, Zhou, Wenlai
Опубликовано 2013

The potent and selective cyclin-dependent kinases 4 and 6 inhibitor ribociclib (LEE011) is a versatile combination partner in preclinical cancer models

по Kim, Sunkyu, Tiedt, Ralph, Loo, Alice, Horn, Thomas, Delach, Scott, Kovats, Steven, Haas, Kristy, Engstler, Barbara Schacher, Cao, Alexander, Pinzon-Ortiz, Maria, Mulford, Iain, Acker, Michael G., Chopra, Rajiv, Brain, Christopher, di Tomaso, Emmanuelle, Sellers, William R., Caponigro, Giordano
Опубликовано в: Oncotarget (2018)

Correction: The potent and selective cyclin-dependent kinases 4 and 6 inhibitor ribociclib (LEE011) is a versatile combination partner in preclinical cancer models

по Kim, Sunkyu, Tiedt, Ralph, Loo, Alice, Horn, Thomas, Delach, Scott, Kovats, Steven, Haas, Kristy, Engstler, Barbara Schacher, Cao, Alexander, Pinzon-Ortiz, Maria, Mulford, Iain, Acker, Michael G., Chopra, Rajiv, Brain, Christopher, Tomaso, Emmanuelle di, Sellers, William R., Caponigro, Giordano
Опубликовано в: Oncotarget (2020)

Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/β-catenin signaling

по Scholer-Dahirel, Alix, Schlabach, Michael R., Loo, Alice, Bagdasarian, Linda, Meyer, Ronald, Guo, Ribo, Woolfenden, Steve, Yu, Kristine K., Markovits, Judit, Killary, Karen, Sonkin, Dmitry, Yao, Yung-Mae, Warmuth, Markus, Sellers, William R., Schlegel, Robert, Stegmeier, Frank, Mosher, Rebecca E., McLaughlin, Margaret E.
Опубликовано 2011

Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition

по Fassl, Anne, Brain, Christopher, Abu-Remaileh, Monther, Stukan, Iga, Butter, Deborah, Stepien, Piotr, Feit, Avery S., Bergholz, Johann, Michowski, Wojciech, Otto, Tobias, Sheng, Qing, Loo, Alice, Michael, Walter, Tiedt, Ralph, DeAngelis, Carmine, Schiff, Rachel, Jiang, Baishan, Jovanovic, Bojana, Nowak, Karolina, Ericsson, Maria, Cameron, Michael, Gray, Nathanael, Dillon, Deborah, Zhao, Jean J., Sabatini, David M., Jeselsohn, Rinath, Brown, Myles, Polyak, Kornelia, Sicinski, Piotr
Опубликовано в: Sci Adv (2020)

A proof of concept for biomarker-guided targeted therapy against ovarian cancer based on patient-derived tumor xenografts

по Palmer, Adam C., Plana, Deborah, Gao, Hui, Korn, Joshua M., Yang, Guizhi, Green, John, Zhang, Xiamei, Velazquez, Roberto, McLaughlin, Margaret E., Ruddy, David A., Kowal, Colleen, Goldovitz, Julie, Bullock, Caroline, Rivera, Stacy, Rakiec, Daniel P., Elliott, GiNell, Fordjour, Paul, Meyer, Ronald, Loo, Alice, Kurth, Esther, Engelman, Jeffrey A., Bitter, Hans, Sellers, William R., Williams, Juliet A., Sorger, Peter K.
Опубликовано в: Cancer Res (2020)

Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors

по Cho, Young Shin, Angove, Hayley, Brain, Christopher, Chen, Christine Hiu-Tung, Cheng, Hong, Cheng, Robert, Chopra, Rajiv, Chung, Kristy, Congreve, Miles, Dagostin, Claudio, Davis, Deborah J., Feltell, Ruth, Giraldes, John, Hiscock, Steven D., Kim, Sunkyu, Kovats, Steven, Lagu, Bharat, Lewry, Kim, Loo, Alice, Lu, Yipin, Luzzio, Michael, Maniara, Wiesia, McMenamin, Rachel, Mortenson, Paul N., Benning, Rajdeep, O'Reilly, Marc, Rees, David C., Shen, Junqing, Smith, Troy, Wang, Yaping, Williams, Glyn, Woolford, Alison J.-A., Wrona, Wojciech, Xu, Mei, Yang, Fan, Howard, Steven
Опубликовано 2012

The landscape of somatic copy-number alteration across human cancers

по Beroukhim, Rameen, Mermel, Craig H., Porter, Dale, Wei, Guo, Raychaudhuri, Soumya, Donovan, Jerry, Barretina, Jordi, Boehm, Jesse S., Dobson, Jennifer, Urashima, Mitsuyoshi, Mc Henry, Kevin T., Pinchback, Reid M., Ligon, Azra H., Cho, Yoon-Jae, Haery, Leila, Greulich, Heidi, Reich, Michael, Winckler, Wendy, Lawrence, Michael S., Weir, Barbara A., Tanaka, Kumiko E., Chiang, Derek Y., Bass, Adam J., Loo, Alice, Hoffman, Carter, Prensner, John, Liefeld, Ted, Gao, Qing, Yecies, Derek, Signoretti, Sabina, Maher, Elizabeth, Kaye, Frederic J., Sasaki, Hidefumi, Tepper, Joel E., Fletcher, Jonathan A., Tabernero, Josep, Baselga, Jose, Tsao, Ming-Sound, DeMichelis, Francesca, Rubin, Mark A., Janne, Pasi A., Daly, Mark J., Nucera, Carmelo, Levine, Ross L., Ebert, Benjamin L., Gabriel, Stacey, Rustgi, Anil K., Antonescu, Cristina R., Ladanyi, Marc, Letai, Anthony, Garraway, Levi A., Loda, Massimo, Beer, David G., True, Lawrence D., Okamoto, Aikou, Pomeroy, Scott L., Singer, Samuel, Golub, Todd R., Lander, Eric S., Getz, Gad, Sellers, William R., Meyerson, Matthew
Опубликовано 2010