Isocitrate Dehydrogenase (IDH) Mutations Promote a Reversible ZEB1/MicroRNA (miR)-200-dependent Epithelial-Mesenchymal Transition (EMT)

Por Grassian, Alexandra R., Lin, Fallon, Barrett, Rosemary, Liu, Yue, Jiang, Wei, Korpal, Manav, Astley, Holly, Gitterman, Daniel, Henley, Thomas, Howes, Rob, Levell, Julian, Korn, Joshua M., Pagliarini, Raymond
Publicado em 2012

A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein

Por Pop, Marius S, Stransky, Nicolas, Garvie, Colin W, Theurillat, Jean-Philippe, Lewis, Timothy A, Zhong, Cheng, Culyba, Elizabeth K, Lin, Fallon, Daniels, Douglas S, Pagliarini, Raymond, Ronco, Lucienne, Koehler, Angela N, Garraway, Levi A
Publicado em 2014

Patient-derived glioblastoma cultures as a tool for small-molecule drug discovery

Por Ye, Ling F., Reznik, Eduard, Korn, Joshua M., Lin, Fallon, Yang, Guizhi, Malesky, Kimberly, Gao, Hui, Loo, Alice, Pagliarini, Raymond, Mikkelsen, Tom, Lo, Donald C., deCarvalho, Ana C., Stockwell, Brent R.
Publicado no Oncotarget (2020)

IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism

Por Grassian, Alexandra R., Parker, Seth J., Davidson, Shawn M., Divakarun, Ajit S., Green, Courtney R., Zhang, Xiamei, Slocum, Kelly L., Pu, Minying, Lin, Fallon, Vickers, Chad, Joud-Caldwell, Carol, Chung, Franklin, Yin, Hong, Handly, Erika D., Straub, Christopher, Growney, Joseph D., Vander Heiden, Matthew G., Murphy, Anne N., Pagliarini, Raymond, Metallo, Christian M.
Publicado no Cancer Res (2014)

ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor

Por Mounir, Zineb, Korn, Joshua M, Westerling, Thomas, Lin, Fallon, Kirby, Christina A, Schirle, Markus, McAllister, Gregg, Hoffman, Greg, Ramadan, Nadire, Hartung, Anke, Feng, Yan, Kipp, David Randal, Quinn, Christopher, Fodor, Michelle, Baird, Jason, Schoumacher, Marie, Meyer, Ronald, Deeds, James, Buchwalter, Gilles, Stams, Travis, Keen, Nicholas, Sellers, William R, Brown, Myles, Pagliarini, Raymond A
Publicado no eLife (2016)

Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1

Por Levell, Julian R., Caferro, Thomas, Chenail, Gregg, Dix, Ina, Dooley, Julia, Firestone, Brant, Fortin, Pascal D., Giraldes, John, Gould, Ty, Growney, Joseph D., Jones, Michael D., Kulathila, Raviraj, Lin, Fallon, Liu, Gang, Mueller, Arne, van der Plas, Simon, Slocum, Kelly, Smith, Troy, Terranova, Remi, Touré, B. Barry, Tyagi, Viraj, Wagner, Trixie, Xie, Xiaoling, Xu, Ming, Yang, Fan S., Zhou, Liping X., Pagliarini, Raymond, Cho, Young Shin
Publicado no ACS Med Chem Lett (2016)