The landscape of kinase fusions in cancer

por Stransky, Nicolas, Cerami, Ethan, Schalm, Stefanie, Kim, Joseph L., Lengauer, Christoph
Publicado 2014

Targeting cancer with kinase inhibitors

por Gross, Stefan, Rahal, Rami, Stransky, Nicolas, Lengauer, Christoph, Hoeflich, Klaus P.
Publicado en J Clin Invest (2015)

Accuracy assessment of fusion transcript detection via read-mapping and de novo fusion transcript assembly-based methods

por Haas, Brian J., Dobin, Alexander, Li, Bo, Stransky, Nicolas, Pochet, Nathalie, Regev, Aviv
Publicado en Genome Biol (2019)

Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer

por Dutt, Amit, Ramos, Alex H., Hammerman, Peter S., Mermel, Craig, Cho, Jeonghee, Sharifnia, Tanaz, Chande, Ajit, Tanaka, Kumiko Elisa, Stransky, Nicolas, Greulich, Heidi, Gray, Nathanael S., Meyerson, Matthew
Publicado 2011

A Novel Epigenetic Phenotype Associated With the Most Aggressive Pathway of Bladder Tumor Progression

por Vallot, Céline, Stransky, Nicolas, Bernard-Pierrot, Isabelle, Hérault, Aurélie, Zucman-Rossi, Jessica, Chapeaublanc, Elodie, Vordos, Dimitri, Laplanche, Agnès, Benhamou, Simone, Lebret, Thierry, Southgate, Jennifer, Allory, Yves, Radvanyi, François
Publicado 2011

A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein

por Pop, Marius S, Stransky, Nicolas, Garvie, Colin W, Theurillat, Jean-Philippe, Lewis, Timothy A, Zhong, Cheng, Culyba, Elizabeth K, Lin, Fallon, Daniels, Douglas S, Pagliarini, Raymond, Ronco, Lucienne, Koehler, Angela N, Garraway, Levi A
Publicado 2014

Nuclear factor I/B is an oncogene in small cell lung cancer

por Dooley, Alison L., Winslow, Monte M., Chiang, Derek Y., Banerji, Shantanu, Stransky, Nicolas, Dayton, Talya L., Snyder, Eric L., Senna, Stephanie, Whittaker, Charles A., Bronson, Roderick T., Crowley, Denise, Barretina, Jordi, Garraway, Levi, Meyerson, Matthew, Jacks, Tyler
Publicado 2011

Genomic analyses of gynaecologic carcinosarcomas reveal frequent mutations in chromatin remodelling genes

por Jones, Siân, Stransky, Nicolas, McCord, Christine L., Cerami, Ethan, Lagowski, James, Kelly, Devon, Angiuoli, Samuel V., Sausen, Mark, Kann, Lisa, Shukla, Manish, Makar, Rosemary, Wood, Laura D., Diaz, Luis A., Lengauer, Christoph, Velculescu, Victor E.
Publicado en Nat Commun (2014)

TYRO3 as a molecular target for growth inhibition and apoptosis induction in bladder cancer

por Dufour, Florent, Silina, Linda, Neyret-Kahn, Hélène, Moreno-Vega, Aura, Krucker, Clémentine, Karboul, Narjesse, Dorland-Galliot, Marion, Maillé, Pascale, Chapeaublanc, Elodie, Allory, Yves, Stransky, Nicolas, Haegel, Hélène, Menguy, Thierry, Duong, Vanessa, Radvanyi, François, Bernard-Pierrot, Isabelle
Publicado en Br J Cancer (2019)

ATARiS: Computational quantification of gene suppression phenotypes from multisample RNAi screens

por Shao, Diane D., Tsherniak, Aviad, Gopal, Shuba, Weir, Barbara A., Tamayo, Pablo, Stransky, Nicolas, Schumacher, Steven E., Zack, Travis I., Beroukhim, Rameen, Garraway, Levi A., Margolin, Adam A., Root, David E., Hahn, William C., Mesirov, Jill P.
Publicado 2013

Consistency of drug profiles and predictors in large-scale cancer cell line data

por Stransky, Nicolas, Ghandi, Mahmoud, Kryukov, Gregory V., Garraway, Levi A., Amzallag, Arnaud, Pruteanu-Malinici, Iulian, Haber, Daniel A., Ramaswamy, Sridhar, Benes, Cyril H., Lehár, Joseph, Liu, Manway, Sonkin, Dmitriy, Kauffmann, Audrey, Venkatesan, Kavitha, Edelman, Elena J., Riester, Markus, Barretina, Jordi, Caponigro, Giordano, Schlegel, Robert, Sellers, William, Stegmeier, Frank, Morrissey, Michael, Menden, Michael P., Iorio, Francesco, Stratton, Michael R., McDermott, Ultan, Saez-Rodriguez, Julio, Garnett, Mathew J.
Publicado en Nature (2015)

Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma

por Van Allen, Eliezer M., Lui, Vivian W. Y., Egloff, Ann Marie, Goetz, Eva M., Li, Hua, Johnson, Jonas T., Duvvuri, Umamaheswar, Bauman, Julie E., Stransky, Nicolas, Zeng, Yan, Gilbert, Breean R., Pendleton, Kelsey P., Wang, Lin, Chiosea, Simion, Sougnez, Carrie, Wagle, Nikhil, Zhang, Fan, Du, Yu, Close, David, Johnston, Paul A., McKenna, Aaron, Carter, Scott L., Golub, Todd R., Getz, Gad, Mills, Gordon B., Garraway, Levi A., Grandis, Jennifer R.
Publicado en JAMA Oncol (2015)

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

por Cheung, Hiu Wing, Cowley, Glenn S., Weir, Barbara A., Boehm, Jesse S., Rusin, Scott, Scott, Justine A., East, Alexandra, Ali, Levi D., Lizotte, Patrick H., Wong, Terence C., Jiang, Guozhi, Hsiao, Jessica, Mermel, Craig H., Getz, Gad, Barretina, Jordi, Gopal, Shuba, Tamayo, Pablo, Gould, Joshua, Tsherniak, Aviad, Stransky, Nicolas, Luo, Biao, Ren, Yin, Drapkin, Ronny, Bhatia, Sangeeta N., Mesirov, Jill P., Garraway, Levi A., Meyerson, Matthew, Lander, Eric S., Root, David E., Hahn, William C.
Publicado 2011

Functional genomics reveals serine synthesis is essential in PHGDH-amplified breast cancer

por Possemato, Richard, Marks, Kevin M., Shaul, Yoav D., Pacold, Michael E., Kim, Dohoon, Birsoy, Kivanç, Sethumadhavan, Shalini, Woo, Hin-Koon, Jang, Hyun G., Jha, Abhishek K., Chen, Walter W., Barrett, Francesca G., Stransky, Nicolas, Tsun, Zhi-Yang, Cowley, Glenn S., Barretina, Jordi, Kalaany, Nada Y., Hsu, Peggy P., Ottina, Kathleen, Chan, Albert M., Yuan, Bingbing, Garraway, Levi A., Root, David E., Mino-Kenudson, Mari, Brachtel, Elena F., Driggers, Edward M., Sabatini, David M.
Publicado 2011

An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules

por Basu, Amrita, Bodycombe, Nicole E., Cheah, Jaime H., Price, Edmund V., Liu, Ke, Schaefer, Giannina I., Ebright, Richard Y., Stewart, Michelle L., Ito, Daisuke, Wang, Stephanie, Bracha, Abigail L., Liefeld, Ted, Wawer, Mathias, Gilbert, Joshua C., Wilson, Andrew J., Stransky, Nicolas, Kryukov, Gregory V., Dancik, Vlado, Barretina, Jordi, Garraway, Levi A., Hon, C. Suk-Yee, Munoz, Benito, Bittker, Joshua A., Stockwell, Brent R., Khabele, Dineo, Stern, Andrew M., Clemons, Paul A., Shamji, Alykhan F., Schreiber, Stuart L.
Publicado 2013

COT/MAP3K8 drives resistance to RAF inhibition through MAP kinase pathway reactivation

por Johannessen, Cory M., Boehm, Jesse S., Kim, So Young, Thomas, Sapana R., Wardwell, Leslie, Johnson, Laura A., Emery, Caroline M., Stransky, Nicolas, Cogdill, Alexandria P., Barretina, Jordi, Caponigro, Giordano, Hieronymus, Haley, Murray, Ryan R., Salehi-Ashtiani, Kourosh, Hill, David E., Vidal, Marc, Zhao, Jean J., Yang, Xiaoping, Alkan, Ozan, Kim, Sungjoon, Harris, Jennifer L., Wilson, Christopher J., Myer, Vic E., Finan, Peter M., Root, David E., Roberts, Thomas M., Golub, Todd, Flaherty, Keith T., Dummer, Reinhard, Weber, Barbara, Sellers, William R., Schlegel, Robert, Wargo, Jennifer A., Hahn, William C., Garraway, Levi A.
Publicado 2010

Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing

por Lohr, Jens G., Stojanov, Petar, Lawrence, Michael S., Auclair, Daniel, Chapuy, Bjoern, Sougnez, Carrie, Cruz-Gordillo, Peter, Knoechel, Birgit, Asmann, Yan W., Slager, Susan L., Novak, Anne J., Dogan, Ahmet, Ansell, Stephen M., Link, Brian K., Zou, Lihua, Gould, Joshua, Saksena, Gordon, Stransky, Nicolas, Rangel-Escareño, Claudia, Fernandez-Lopez, Juan Carlos, Hidalgo-Miranda, Alfredo, Melendez-Zajgla, Jorge, Hernández-Lemus, Enrique, Schwarz-Cruz y Celis, Angela, Imaz-Rosshandler, Ivan, Ojesina, Akinyemi I., Jung, Joonil, Pedamallu, Chandra S., Lander, Eric S., Habermann, Thomas M., Cerhan, James R., Shipp, Margaret A., Getz, Gad, Golub, Todd R.
Publicado 2012

Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion

por Bass, Adam J, Lawrence, Michael S, Brace, Lear E, Ramos, Alex H, Drier, Yotam, Cibulskis, Kristian, Sougnez, Carrie, Voet, Douglas, Saksena, Gordon, Sivachenko, Andrey, Jing, Rui, Parkin, Melissa, Pugh, Trevor, Verhaak, Roel G, Stransky, Nicolas, Boutin, Adam T, Barretina, Jordi, Solit, David B, Vakiani, Evi, Shao, Wenlin, Mishina, Yuji, Warmuth, Markus, Jimenez, Jose, Chiang, Derek Y, Signoretti, Sabina, Kaelin, William G, Spardy, Nicole, Hahn, William C, Hoshida, Yujin, Ogino, Shuji, DePinho, Ronald A, Chin, Lynda, Garraway, Levi A, Fuchs, Charles S, Baselga, Jose, Tabernero, Josep, Gabriel, Stacey, Lander, Eric S, Getz, Gad, Meyerson, Matthew
Publicado 2011

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

por Stransky, Nicolas, Egloff, Ann Marie, Tward, Aaron D., Kostic, Aleksandar D., Cibulskis, Kristian, Sivachenko, Andrey, Kryukov, Gregory V., Lawrence, Michael, Sougnez, Carrie, McKenna, Aaron, Shefler, Erica, Ramos, Alex H., Stojanov, Petar, Carter, Scott L., Voet, Douglas, Cortés, Maria L, Auclair, Daniel, Berger, Michael F., Saksena, Gordon, Guiducci, Candace, Onofrio, Robert, Parkin, Melissa, Romkes, Marjorie, Weissfeld, Joel L., Seethala, Raja R., Wang, Lin, Rangel-Escareño, Claudia, Fernandez-Lopez, Juan Carlos, Hidalgo-Miranda, Alfredo, Melendez-Zajgla, Jorge, Winckler, Wendy, Ardlie, Kristin, Gabriel, Stacey B., Meyerson, Matthew, Lander, Eric S., Getz, Gad, Golub, Todd R., Garraway, Levi A., Grandis, Jennifer R.
Publicado 2011

A Landscape of Driver Mutations in Melanoma

por Hodis, Eran, Watson, Ian R., Kryukov, Gregory V., Arold, Stefan T., Imielinski, Marcin, Theurillat, Jean-Philippe, Nickerson, Elizabeth, Auclair, Daniel, Li, Liren, Place, Chelsea, DiCara, Daniel, Ramos, Alex H., Lawrence, Michael S., Cibulskis, Kristian, Sivachenko, Andrey, Voet, Douglas, Saksena, Gordon, Stransky, Nicolas, Onofrio, Robert C., Winckler, Wendy, Ardlie, Kristin, Wagle, Nikhil, Wargo, Jennifer, Chong, Kelly, Morton, Donald L., Stemke-Hale, Katherine, Chen, Guo, Noble, Michael, Meyerson, Matthew, Ladbury, John E., Davies, Michael A., Gershenwald, Jeffrey E., Wagner, Stephan N., Hoon, Dave S.B., Schadendorf, Dirk, Lander, Eric S., Gabriel, Stacey B., Getz, Gad, Garraway, Levi A., Chin, Lynda
Publicado 2012