Resources for the design of CRISPR gene editing experiments

by Graham, Daniel B., Root, David E.
Published in Genome Biol (2015)

Detecting Spatial Patterns in Biological Array Experiments

by ROOT, DAVID E., KELLEY, BRIAN P., STOCKWELL, BRENT R.
Published 2003

Global analysis of large-scale chemical and biological experiments

by Root, David E, Kelley, Brian P, Stockwell, Brent R
Published 2002

Synthetic lethal screening in the mammalian central nervous system identifies Gpx6 as a modulator of Huntington’s disease

by Shema, Reut, Kulicke, Ruth, Cowley, Glenn S., Stein, Rachael, Root, David E., Heiman, Myriam
Published in Proc Natl Acad Sci U S A (2015)

Identification of an Oncogenic RAB Protein

by Wheeler, Douglas B., Zoncu, Roberto, Root, David E., Sabatini, David M., Sawyers, Charles L.
Published in Science (2015)

High-throughput platform for identifying molecular factors involved in phenotypic stabilization of primary human hepatocytes in vitro

by Shan, Jing, Logan, David J., Root, David E., Carpenter, Anne E., Bhatia, Sangeeta N.
Published in J Biomol Screen (2016)

Combined pan-RAF and MEK inhibition overcomes multiple resistance mechanisms to selective RAF inhibitors

by Whittaker, Steven R., Cowley, Glenn S., Wagner, Steve, Luo, Flora, Root, David E., Garraway, Levi A.
Published in Mol Cancer Ther (2015)

Mitochondrial and Nuclear Genomic Responses to Loss of LRPPRC Expression

by Gohil, Vishal M., Nilsson, Roland, Belcher-Timme, Casey A., Luo, Biao, Root, David E., Mootha, Vamsi K.
Published 2010

Correction: Mitochondrial and nuclear genomic responses to loss of LRPPRC expression.

by Gohil, Vishal M., Nilsson, Roland, Belcher-Timme, Casey A., Luo, Biao, Root, David E., Mootha, Vamsi K.
Published in J Biol Chem (2020)

Conserved pathways within bacteria and yeast as revealed by global protein network alignment

by Kelley, Brian P., Sharan, Roded, Karp, Richard M., Sittler, Taylor, Root, David E., Stockwell, Brent R., Ideker, Trey
Published 2003

Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8(+) T-cell effector differentiation

by Godec, Jernej, Cowley, Glenn S., Barnitz, R. Anthony, Alkan, Ozan, Root, David E., Sharpe, Arlene H., Haining, W. Nicholas
Published in Proc Natl Acad Sci U S A (2015)

Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool

by Donovan, Katherine F., Hegde, Mudra, Sullender, Meagan, Vaimberg, Emma W., Johannessen, Cory M., Root, David E., Doench, John G.
Published in PLoS One (2017)

A genome-scale CRISPR screen identifies the ERBB and mTOR signalling networks as key determinants of response to PI3K inhibition in pancreatic cancer

by Milton, Charlotte K., Self, Annette J., Clarke, Paul A., Banerji, Udai, Piccioni, Federica, Root, David E., Whittaker, Steven R.
Published in Mol Cancer Ther (2020)

Receptor Tyrosine Kinases Fall into Distinct Classes Based on Their Inferred Signaling Networks

by Wagner, Joel P., Wolf-Yadlin, Alejandro, Sevecka, Mark, Grenier, Jennifer K., Root, David E., Lauffenburger, Douglas A., MacBeath, Gavin
Published 2013

Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression

by Rosenbluh, Joseph, Xu, Han, Harrington, William, Gill, Stanley, Wang, Xiaoxing, Vazquez, Francisca, Root, David E., Tsherniak, Aviad, Hahn, William C.
Published in Nat Commun (2017)

A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation

by Arroyo, Jason D., Jourdain, Alexis A., Calvo, Sarah E., Ballarano, Carmine A., Doench, John G., Root, David E., Mootha, Vamsi K.
Published in Cell Metab (2016)

A Targeted RNA Interference Screen Reveals Novel Epigenetic Factors That Regulate Herpesviral Gene Expression

by Oh, Hyung Suk, Bryant, Kevin F., Nieland, Thomas J. F., Mazumder, Aprotim, Bagul, Mukta, Bathe, Mark, Root, David E., Knipe, David M.
Published 2014

High Content Image Analysis Identifies Novel Regulators of Synaptogenesis in a High-Throughput RNAi Screen of Primary Neurons

by Nieland, Thomas J. F., Logan, David J., Saulnier, Jessica, Lam, Daniel, Johnson, Caroline, Root, David E., Carpenter, Anne E., Sabatini, Bernardo L.
Published 2014

Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects

by Singh, Shantanu, Wu, Xiaoyun, Ljosa, Vebjorn, Bray, Mark-Anthony, Piccioni, Federica, Root, David E., Doench, John G., Boehm, Jesse S., Carpenter, Anne E.
Published in PLoS One (2015)

Aire-dependent genes undergo Clp1-mediated 3’UTR shortening associated with higher transcript stability in the thymus

by Guyon, Clotilde, Jmari, Nada, Padonou, Francine, Li, Yen-Chin, Ucar, Olga, Fujikado, Noriyuki, Coulpier, Fanny, Blanchet, Christophe, Root, David E, Giraud, Matthieu
Published in eLife (2020)