Resources for the design of CRISPR gene editing experiments

gan Graham, Daniel B., Root, David E.
Cyhoeddwyd yn Genome Biol (2015)

Detecting Spatial Patterns in Biological Array Experiments

gan ROOT, DAVID E., KELLEY, BRIAN P., STOCKWELL, BRENT R.
Cyhoeddwyd 2003

Global analysis of large-scale chemical and biological experiments

gan Root, David E, Kelley, Brian P, Stockwell, Brent R
Cyhoeddwyd 2002

Synthetic lethal screening in the mammalian central nervous system identifies Gpx6 as a modulator of Huntington’s disease

gan Shema, Reut, Kulicke, Ruth, Cowley, Glenn S., Stein, Rachael, Root, David E., Heiman, Myriam
Cyhoeddwyd yn Proc Natl Acad Sci U S A (2015)

Identification of an Oncogenic RAB Protein

gan Wheeler, Douglas B., Zoncu, Roberto, Root, David E., Sabatini, David M., Sawyers, Charles L.
Cyhoeddwyd yn Science (2015)

High-throughput platform for identifying molecular factors involved in phenotypic stabilization of primary human hepatocytes in vitro

gan Shan, Jing, Logan, David J., Root, David E., Carpenter, Anne E., Bhatia, Sangeeta N.
Cyhoeddwyd yn J Biomol Screen (2016)

Combined pan-RAF and MEK inhibition overcomes multiple resistance mechanisms to selective RAF inhibitors

gan Whittaker, Steven R., Cowley, Glenn S., Wagner, Steve, Luo, Flora, Root, David E., Garraway, Levi A.
Cyhoeddwyd yn Mol Cancer Ther (2015)

Mitochondrial and Nuclear Genomic Responses to Loss of LRPPRC Expression

gan Gohil, Vishal M., Nilsson, Roland, Belcher-Timme, Casey A., Luo, Biao, Root, David E., Mootha, Vamsi K.
Cyhoeddwyd 2010

Correction: Mitochondrial and nuclear genomic responses to loss of LRPPRC expression.

gan Gohil, Vishal M., Nilsson, Roland, Belcher-Timme, Casey A., Luo, Biao, Root, David E., Mootha, Vamsi K.
Cyhoeddwyd yn J Biol Chem (2020)

Conserved pathways within bacteria and yeast as revealed by global protein network alignment

gan Kelley, Brian P., Sharan, Roded, Karp, Richard M., Sittler, Taylor, Root, David E., Stockwell, Brent R., Ideker, Trey
Cyhoeddwyd 2003

Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8(+) T-cell effector differentiation

gan Godec, Jernej, Cowley, Glenn S., Barnitz, R. Anthony, Alkan, Ozan, Root, David E., Sharpe, Arlene H., Haining, W. Nicholas
Cyhoeddwyd yn Proc Natl Acad Sci U S A (2015)

Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool

gan Donovan, Katherine F., Hegde, Mudra, Sullender, Meagan, Vaimberg, Emma W., Johannessen, Cory M., Root, David E., Doench, John G.
Cyhoeddwyd yn PLoS One (2017)

A genome-scale CRISPR screen identifies the ERBB and mTOR signalling networks as key determinants of response to PI3K inhibition in pancreatic cancer

gan Milton, Charlotte K., Self, Annette J., Clarke, Paul A., Banerji, Udai, Piccioni, Federica, Root, David E., Whittaker, Steven R.
Cyhoeddwyd yn Mol Cancer Ther (2020)

Receptor Tyrosine Kinases Fall into Distinct Classes Based on Their Inferred Signaling Networks

gan Wagner, Joel P., Wolf-Yadlin, Alejandro, Sevecka, Mark, Grenier, Jennifer K., Root, David E., Lauffenburger, Douglas A., MacBeath, Gavin
Cyhoeddwyd 2013

Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression

gan Rosenbluh, Joseph, Xu, Han, Harrington, William, Gill, Stanley, Wang, Xiaoxing, Vazquez, Francisca, Root, David E., Tsherniak, Aviad, Hahn, William C.
Cyhoeddwyd yn Nat Commun (2017)

A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation

gan Arroyo, Jason D., Jourdain, Alexis A., Calvo, Sarah E., Ballarano, Carmine A., Doench, John G., Root, David E., Mootha, Vamsi K.
Cyhoeddwyd yn Cell Metab (2016)

A Targeted RNA Interference Screen Reveals Novel Epigenetic Factors That Regulate Herpesviral Gene Expression

gan Oh, Hyung Suk, Bryant, Kevin F., Nieland, Thomas J. F., Mazumder, Aprotim, Bagul, Mukta, Bathe, Mark, Root, David E., Knipe, David M.
Cyhoeddwyd 2014

High Content Image Analysis Identifies Novel Regulators of Synaptogenesis in a High-Throughput RNAi Screen of Primary Neurons

gan Nieland, Thomas J. F., Logan, David J., Saulnier, Jessica, Lam, Daniel, Johnson, Caroline, Root, David E., Carpenter, Anne E., Sabatini, Bernardo L.
Cyhoeddwyd 2014

Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects

gan Singh, Shantanu, Wu, Xiaoyun, Ljosa, Vebjorn, Bray, Mark-Anthony, Piccioni, Federica, Root, David E., Doench, John G., Boehm, Jesse S., Carpenter, Anne E.
Cyhoeddwyd yn PLoS One (2015)

Aire-dependent genes undergo Clp1-mediated 3’UTR shortening associated with higher transcript stability in the thymus

gan Guyon, Clotilde, Jmari, Nada, Padonou, Francine, Li, Yen-Chin, Ucar, Olga, Fujikado, Noriyuki, Coulpier, Fanny, Blanchet, Christophe, Root, David E, Giraud, Matthieu
Cyhoeddwyd yn eLife (2020)