Aire-dependent genes undergo Clp1-mediated 3’UTR shortening associated with higher transcript stability in the thymus

The ability of the immune system to avoid autoimmune disease relies on tolerization of thymocytes to self-antigens whose expression and presentation by thymic medullary epithelial cells (mTECs) is controlled predominantly by Aire at the transcriptional level and possibly regulated at other unrecogni...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Guyon, Clotilde, Jmari, Nada, Padonou, Francine, Li, Yen-Chin, Ucar, Olga, Fujikado, Noriyuki, Coulpier, Fanny, Blanchet, Christophe, Root, David E, Giraud, Matthieu
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205469/
https://ncbi.nlm.nih.gov/pubmed/32338592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52985
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