Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression

CRISPR-Cas9 provides the means to perform genome editing and facilitates loss-of-function screens. However, we and others demonstrated that expression of the Cas9 endonuclease induces a gene-independent response that correlates with the number of target sequences in the genome. An alternative approa...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Rosenbluh, Joseph, Xu, Han, Harrington, William, Gill, Stanley, Wang, Xiaoxing, Vazquez, Francisca, Root, David E., Tsherniak, Aviad, Hahn, William C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5457492/
https://ncbi.nlm.nih.gov/pubmed/28534478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15403
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