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Identification of an Oncogenic RAB Protein
In an shRNA screen for genes that affect AKT phosphorylation, we identified the RAB35 small GTPase—a protein previously implicated in endomembrane trafficking—as a new regulator of the PI3K pathway. Depletion of RAB35 suppresses AKT phosphorylation in response to growth factors, whereas expression o...
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| Gepubliceerd in: | Science |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4600465/ https://ncbi.nlm.nih.gov/pubmed/26338797 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa4903 |
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