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Combined pan-RAF and MEK inhibition overcomes multiple resistance mechanisms to selective RAF inhibitors
RAF and MEK inhibitors are effective in BRAF-mutant melanoma but not in BRAF-mutant colorectal cancer. To gain additional insights into this difference, we performed a genome-scale, pooled shRNA enhancer screen in a BRAF-mutant, BRAF-inhibitor resistant colorectal cancer cell line exposed to the sel...
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| Publicado no: | Mol Cancer Ther |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4674359/ https://ncbi.nlm.nih.gov/pubmed/26351322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0136-T |
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