Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Orally Bioavailable and Brain Penetrant Mutant IDH1 Inhibitors

door Zhao, Qian, Manning, James R., Sutton, James, Costales, Abran, Sendzik, Martin, Shafer, Cynthia M., Levell, Julian R., Liu, Gang, Caferro, Thomas, Cho, Young Shin, Palermo, Mark, Chenail, Gregg, Dooley, Julia, Villalba, Brian, Farsidjani, Ali, Chen, Jinyun, Dodd, Stephanie, Gould, Ty, Liang, Guiqing, Slocum, Kelly, Pu, Minying, Firestone, Brant, Growney, Joseph, Heimbach, Tycho, Pagliarini, Raymond
Gepubliceerd in ACS Med Chem Lett (2018)

Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor

door Cho, Young Shin, Levell, Julian R., Liu, Gang, Caferro, Thomas, Sutton, James, Shafer, Cynthia M., Costales, Abran, Manning, James R., Zhao, Qian, Sendzik, Martin, Shultz, Michael, Chenail, Gregg, Dooley, Julia, Villalba, Brian, Farsidjani, Ali, Chen, Jinyun, Kulathila, Raviraj, Xie, Xiaoling, Dodd, Stephanie, Gould, Ty, Liang, Guiqing, Heimbach, Tycho, Slocum, Kelly, Firestone, Brant, Pu, Minying, Pagliarini, Raymond, Growney, Joseph D.
Gepubliceerd in ACS Med Chem Lett (2017)

Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1

door Levell, Julian R., Caferro, Thomas, Chenail, Gregg, Dix, Ina, Dooley, Julia, Firestone, Brant, Fortin, Pascal D., Giraldes, John, Gould, Ty, Growney, Joseph D., Jones, Michael D., Kulathila, Raviraj, Lin, Fallon, Liu, Gang, Mueller, Arne, van der Plas, Simon, Slocum, Kelly, Smith, Troy, Terranova, Remi, Touré, B. Barry, Tyagi, Viraj, Wagner, Trixie, Xie, Xiaoling, Xu, Ming, Yang, Fan S., Zhou, Liping X., Pagliarini, Raymond, Cho, Young Shin
Gepubliceerd in ACS Med Chem Lett (2016)