Targeting HSF1 sensitizes cancer cells to HSP90 inhibition

The molecular chaperone heat shock protein 90 (HSP90) facilitates the appropriate folding of various oncogenic proteins and is necessary for the survival of some cancer cells. HSP90 is therefore an attractive drug target, but the efficacy of HSP90 inhibitor may be limited by HSP90 inhibition induced...

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Bibliographische Detailangaben
Hauptverfasser: Chen, Yaoyu, Chen, Jinyun, Loo, Alice, Jaeger, Savina, Bagdasarian, Linda, Yu, Jianjun, Chung, Franklin, Korn, Joshua, Ruddy, David, Guo, Ribo, Mclaughlin, Margaret E., Feng, Fei, Zhu, Ping, Stegmeier, Frank, Pagliarini, Raymond, Porter, Dale, Zhou, Wenlai
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2013
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757240/
https://ncbi.nlm.nih.gov/pubmed/23615731
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