Targeting HSF1 disrupts HSP90 chaperone function in chronic lymphocytic leukemia

CLL is a disease characterized by chromosomal deletions, acquired copy number changes and aneuploidy. Recent studies have shown that overexpression of Heat Shock Factor (HSF) 1 in aneuploid tumor cells can overcome deficiencies in heat shock protein (HSP) 90-mediated protein folding and restore prot...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ganguly, Siddhartha, Home, Trisha, Yacoub, Abdulraheem, Kambhampati, Suman, Shi, Huidong, Dandawate, Prasad, Padhye, Subhash, Saluja, Ashok K., McGuirk, Joseph, Rao, Rekha
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741638/
https://ncbi.nlm.nih.gov/pubmed/26397138
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