Chaperone Activity and Dimerization Properties of Hsp90α and Hsp90β in Glucocorticoid Receptor Activation by the Multiprotein Hsp90/Hsp70-Dependent Chaperone Machinery

Several hundred proteins cycle into heterocomplexes with a dimer of the chaperone heat shock protein 90 (Hsp90), regulating their activity and turnover. There are two isoforms of Hsp90, Hsp90α and Hsp90β, and their relative chaperone activities and composition in these client protein•Hsp90 heterocom...

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Publicado no:Mol Pharmacol
Main Authors: Morishima, Yoshihiro, Mehta, Ranjit K., Yoshimura, Miyako, Lau, Miranda, Southworth, Daniel R., Lawrence, Theodore S., Pratt, William B., Nyati, Mukesh K., Osawa, Yoichi
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6064783/
https://ncbi.nlm.nih.gov/pubmed/29941666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.112516
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