A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53

Through targeted homologous recombination, we developed a panel of matched colorectal cancer cell lines that differ only with respect to their endogenous TP53 status. We then used these lines to define the genes whose expression was altered after DNA damage induced by ionizing radiation. Transcripto...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sur, Surojit, Pagliarini, Raymond, Bunz, Fred, Rago, Carlo, Diaz, Luis A., Kinzler, Kenneth W., Vogelstein, Bert, Papadopoulos, Nickolas
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2009
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656188/
https://ncbi.nlm.nih.gov/pubmed/19225112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813333106
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