A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53

Through targeted homologous recombination, we developed a panel of matched colorectal cancer cell lines that differ only with respect to their endogenous TP53 status. We then used these lines to define the genes whose expression was altered after DNA damage induced by ionizing radiation. Transcripto...

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Detaylı Bibliyografya
Asıl Yazarlar: Sur, Surojit, Pagliarini, Raymond, Bunz, Fred, Rago, Carlo, Diaz, Luis A., Kinzler, Kenneth W., Vogelstein, Bert, Papadopoulos, Nickolas
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2009
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656188/
https://ncbi.nlm.nih.gov/pubmed/19225112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813333106
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