Disruption of p53 in human cancer cells alters the responses to therapeutic agents

We have examined the effects of commonly used chemotherapeutic agents on human colon cancer cell lines in which the p53 pathway has been specifically disrupted by targeted homologous recombination. We found that p53 had profound effects on drug responses, and these effects varied dramatically depend...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Clin Invest
Egile Nagusiak: Bunz, Fred, Hwang, Paul M., Torrance, Chris, Waldman, Todd, Zhang, Yonggang, Dillehay, Larry, Williams, Jerry, Lengauer, Christoph, Kinzler, Kenneth W., Vogelstein, Bert
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 1999
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC408422/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10430607/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI6863
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