Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation

Phosphotidylinositol-3-kinase (PI3K) signaling is altered in the majority of human cancers. To gain insight into the roles of members of this pathway in growth regulation, we inactivated AKT1, AKT2, or PDPK1 genes by targeted homologous recombination in human colon cancer cell lines. Knockout of eit...

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Detalles Bibliográficos
Autores principales: Ericson, Kajsa, Gan, Christine, Cheong, Ian, Rago, Carlo, Samuels, Yardena, Velculescu, Victor E., Kinzler, Kenneth W., Huso, David L., Vogelstein, Bert, Papadopoulos, Nickolas
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2010
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823889/
https://ncbi.nlm.nih.gov/pubmed/20133737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914018107
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