Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation

Phosphotidylinositol-3-kinase (PI3K) signaling is altered in the majority of human cancers. To gain insight into the roles of members of this pathway in growth regulation, we inactivated AKT1, AKT2, or PDPK1 genes by targeted homologous recombination in human colon cancer cell lines. Knockout of eit...

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Detalhes bibliográficos
Main Authors: Ericson, Kajsa, Gan, Christine, Cheong, Ian, Rago, Carlo, Samuels, Yardena, Velculescu, Victor E., Kinzler, Kenneth W., Huso, David L., Vogelstein, Bert, Papadopoulos, Nickolas
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823889/
https://ncbi.nlm.nih.gov/pubmed/20133737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914018107
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